HEL111 FISH Probe
The HEL111 FISH probe is designed to hybridize to the HEL111 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TTR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TTR-20-RE | 20 (40 μL) | 200 μL |  |
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| TTR-20-GO | 20 (40 μL) | 200 μL |  |
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| TTR-20-GR | 20 (40 μL) | 200 μL |  |
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| TTR-20-AQ | 20 (40 μL) | 200 μL |  |
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| TTR-20-DIG | 20 (40 μL) | 200 μL |  |
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| TTR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: TTR
Gene Name: Transthyretin
Chromosome: CHR18: 29171729-29178986
Locus: 18q12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HEL111 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TTR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping