HEL-216 FISH Probe
The HEL-216 FISH probe is designed to hybridize to the HEL-216 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IDH1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IDH1-20-RE | 20 (40 μL) | 200 μL |  |
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| IDH1-20-GO | 20 (40 μL) | 200 μL |  |
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| IDH1-20-GR | 20 (40 μL) | 200 μL |  |
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| IDH1-20-AQ | 20 (40 μL) | 200 μL |  |
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| IDH1-20-DIG | 20 (40 μL) | 200 μL |  |
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| IDH1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Details
Gene Symbol: IDH1
Gene Name: Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic
Chromosome: CHR2: 209100952-209119806
Locus: 2q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HEL-216 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IDH1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping