HECW2 FISH Probe
The HECW2 FISH probe is designed to hybridize to the HECW2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HECW2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HECW2-20-RE | 20 (40 μL) | 200 μL |  |
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| HECW2-20-GO | 20 (40 μL) | 200 μL |  |
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| HECW2-20-GR | 20 (40 μL) | 200 μL |  |
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| HECW2-20-AQ | 20 (40 μL) | 200 μL |  |
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| HECW2-20-DIG | 20 (40 μL) | 200 μL |  |
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| HECW2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Details
Gene Symbol: HECW2
Gene Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR2: 197063976-197457335
Locus: 2q32.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HECW2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HECW2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping