GRIA2 FISH Probe
The GRIA2 FISH probe is designed to hybridize to the GRIA2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GRIA2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-RE | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-GO | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-GR | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-AQ | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-DIG | 20 (40 μL) | 200 μL |  |
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| GRIA2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: GRIA2
Gene Name: Glutamate Ionotropic Receptor AMPA Type Subunit 2
Chromosome: CHR4: 158141735-158287226
Locus: 4q32.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GRIA2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GRIA2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping