GAP FISH Probe
The GAP FISH probe is designed to hybridize to the GAP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RASA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RASA1-20-RE | 20 (40 μL) | 200 μL |  |
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| RASA1-20-GO | 20 (40 μL) | 200 μL |  |
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| RASA1-20-GR | 20 (40 μL) | 200 μL |  |
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| RASA1-20-AQ | 20 (40 μL) | 200 μL |  |
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| RASA1-20-DIG | 20 (40 μL) | 200 μL |  |
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| RASA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Gene Details
Gene Symbol: RASA1
Gene Name: RAS P21 Protein Activator 1
Chromosome: CHR5: 86564150-86687733
Locus: 5q14.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GAP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RASA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping