FX FISH Probe
The FX FISH probe is designed to hybridize to the FX gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| F10-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| F10-20-RE | 20 (40 μL) | 200 μL |  |
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| F10-20-GO | 20 (40 μL) | 200 μL |  |
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| F10-20-GR | 20 (40 μL) | 200 μL |  |
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| F10-20-AQ | 20 (40 μL) | 200 μL |  |
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| F10-20-DIG | 20 (40 μL) | 200 μL |  |
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| F10-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: F10
Gene Name: Coagulation Factor X
Chromosome: CHR13: 113777112-113803843
Locus: 13q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FX FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: F10-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping