FHOS2 FISH Probe
The FHOS2 FISH probe is designed to hybridize to the FHOS2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FHOD3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-RE | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-GO | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-GR | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-AQ | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-DIG | 20 (40 μL) | 200 μL |  |
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| FHOD3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: FHOD3
Gene Name: Formin Homology 2 Domain Containing 3
Chromosome: CHR18: 33877701-34360018
Locus: 18q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FHOS2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FHOD3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping