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FGF4 FISH Probe

The FGF4 FISH probe is designed to hybridize to the FGF4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
FGF4-20-OR  (Standard Design) 20 (40 μL) 200 μL
FGF4-20-RE 20 (40 μL) 200 μL
FGF4-20-GO 20 (40 μL) 200 μL
FGF4-20-GR 20 (40 μL) 200 μL
FGF4-20-AQ 20 (40 μL) 200 μL
FGF4-20-DIG 20 (40 μL) 200 μL
FGF4-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: FGF4

Gene Name: Fibroblast Growth Factor 4

Chromosome: CHR11: 69587796-69590171

Locus: 11q13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Poor prognostic impact of FGF4 amplification in patients with esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of esophageal cancer and has a poor prognosis. The FGF4 gene was analyzed to determine the prognostic impact and clinicopathological features associated with amplification. FISH analysis was used with our FGF4 probe to detect the amplification status of the gene. It was found that those with the FGF4 amplification showed a significantly shorter disease-free and overall survival compared to those without the amplification. Therefore, the presence or absence of FGF4 amplification can be used to give patients a predictor for how much longer they can expect to live.
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Product Details

Product: FGF4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: FGF4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping