EWS RNA- FISH Probe
The EWS RNA- FISH probe is designed to hybridize to the EWS RNA- gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EWSR1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-RE | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-GO | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-GR | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-AQ | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-DIG | 20 (40 μL) | 200 μL |  |
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| EWSR1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Gene Details
Gene Symbol: EWSR1
Gene Name: EWS RNA Binding Protein 1
Chromosome: CHR22: 29663997-29696515
Locus: 22q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: EWS RNA- FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: EWSR1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping