EST2 FISH Probe
The EST2 FISH probe is designed to hybridize to the EST2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TERT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TERT-20-RE | 20 (40 μL) | 200 μL |  |
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| TERT-20-GO | 20 (40 μL) | 200 μL |  |
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| TERT-20-GR | 20 (40 μL) | 200 μL |  |
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| TERT-20-AQ | 20 (40 μL) | 200 μL |  |
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| TERT-20-DIG | 20 (40 μL) | 200 μL |  |
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| TERT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: TERT
Gene Name: Telomerase Reverse Transcriptase
Chromosome: CHR5: 1253286-1295162
Locus: 5p15.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: EST2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TERT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping