ERBB4 FISH Probe

The ERBB4 FISH probe is designed to hybridize to the ERBB4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping

Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU	Test Kits	Buffer
ERBB4-20-OR (Standard Design)	20 (40 μL)	200 μL
ERBB4-20-RE	20 (40 μL)	200 μL
ERBB4-20-GO	20 (40 μL)	200 μL
ERBB4-20-GR	20 (40 μL)	200 μL
ERBB4-20-AQ	20 (40 μL)	200 μL
ERBB4-20-DIG	20 (40 μL)	200 μL
ERBB4-20-BIO	20 (40 μL)	200 μL

Gene Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: ERBB4

Gene Name: Erb-b2 Receptor Tyrosine Kinase 4

Chromosome: CHR2: 212240441-213403352

Locus: 2q34

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma

Chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO) are two tumors that are difficult to distinguish from one another. It is important to distinguish them because ChRCC is a malignant tumor whereas RO is a benign tumor. Deletion of the RB1 and ERBB4 genes are indicative of ChRCC because these are tumor-suppressant genes. FISH analysis was used to identify these deletions. Our dual color probes were used that targeted RB1-Orange (MAC clone RP11-893E5) and 13q11-Green (RP11-408E5). A green ERBB4 probe was also used.

The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma

Renal oncocytoma (RO) is a benign epithelial neoplasm that makes up about 5 to 9% of all renal cell tumors. RO can be difficult to distinguish from a closely related but malignant counterpart, chromophobe renal cell carcinoma (ChrCC). This study used both IHC and FISH to detect the presence of RB1 and ERBB4, two genes that have been found deleted in ChrCC but not RO. A total of 28 ChrCCs and 25 RO cases were tested. Empire Genomics’ RB1 and ERBB4 FISH probes were used to detect deletions in these genes.

Product Details

Product: ERBB4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ERBB4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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