ERBB3 FISH Probe
The ERBB3 FISH probe is designed to hybridize to the ERBB3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERBB3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-RE | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-GO | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-GR | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-AQ | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-DIG | 20 (40 μL) | 200 μL |  |
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| ERBB3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ERBB3
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808-56497291
Locus: 12q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ERBB3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ERBB3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping