DROSHA FISH Probe
The DROSHA FISH probe is designed to hybridize to the DROSHA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DROSHA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-RE | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-GO | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-GR | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-AQ | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-DIG | 20 (40 μL) | 200 μL |  |
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| DROSHA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
Gene Details
Gene Symbol: DROSHA
Gene Name: Drosha Ribonuclease III
Chromosome: CHR5: 31400601-31532282
Locus: 5p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DROSHA FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DROSHA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping