DR4 FISH Probe
The DR4 FISH probe is designed to hybridize to the DR4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DRB4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-DRB4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-DRB4
Gene Name: Major Histocompatibility Complex, Class II, DR Beta 4
Chromosome: CHR6_mcf_hap5: 3882323-3897292
Locus: 6p21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DR4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-DRB4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping