DNMT3L FISH Probe
The DNMT3L FISH probe is designed to hybridize to the DNMT3L gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DNMT3L-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-RE | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-GO | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-GR | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-AQ | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-DIG | 20 (40 μL) | 200 μL |  |
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| DNMT3L-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Details
Gene Symbol: DNMT3L
Gene Name: DNA Methyltransferase 3 Like
Chromosome: CHR21: 45666222-45682099
Locus: 21q22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DNMT3L FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DNMT3L-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping