DLAT FISH Probe
The DLAT FISH probe is designed to hybridize to the DLAT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DLAT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DLAT-20-RE | 20 (40 μL) | 200 μL |  |
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| DLAT-20-GO | 20 (40 μL) | 200 μL |  |
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| DLAT-20-GR | 20 (40 μL) | 200 μL |  |
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| DLAT-20-AQ | 20 (40 μL) | 200 μL |  |
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| DLAT-20-DIG | 20 (40 μL) | 200 μL |  |
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| DLAT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: DLAT
Gene Name: Dihydrolipoamide S-acetyltransferase
Chromosome: CHR11: 111895537-111935002
Locus: 11q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DLAT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DLAT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping