DHCR7 FISH Probe
The DHCR7 FISH probe is designed to hybridize to the DHCR7 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DHCR7-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-RE | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-GO | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-GR | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-AQ | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-DIG | 20 (40 μL) | 200 μL |  |
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| DHCR7-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]
Gene Details
Gene Symbol: DHCR7
Gene Name: 7-dehydrocholesterol Reductase
Chromosome: CHR11: 71145456-71159477
Locus: 11q13.4
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DHCR7 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DHCR7-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping