DAPAL FISH Probe
The DAPAL FISH probe is designed to hybridize to the DAPAL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HOGA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-RE | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-GO | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-GR | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| HOGA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Gene Details
Gene Symbol: HOGA1
Gene Name: 4-hydroxy-2-oxoglutarate Aldolase 1
Chromosome: CHR10: 99344101-99372555
Locus: 10q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: DAPAL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HOGA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping