DAB2 FISH Probe
The DAB2 FISH probe is designed to hybridize to the DAB2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DAB2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DAB2-20-RE | 20 (40 μL) | 200 μL |  |
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| DAB2-20-GO | 20 (40 μL) | 200 μL |  |
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| DAB2-20-GR | 20 (40 μL) | 200 μL |  |
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| DAB2-20-AQ | 20 (40 μL) | 200 μL |  |
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| DAB2-20-DIG | 20 (40 μL) | 200 μL |  |
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| DAB2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Details
Gene Symbol: DAB2
Gene Name: DAB2, Clathrin Adaptor Protein
Chromosome: CHR5: 39371779-39425335
Locus: 5p13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DAB2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DAB2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping