CYCLE FISH Probe
The CYCLE FISH probe is designed to hybridize to the CYCLE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CCNE1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-RE | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-GO | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-GR | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| CCNE1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: CCNE1
Gene Name: Cyclin E1
Chromosome: CHR19: 30302900-30315215
Locus: 19q12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: CYCLE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CCNE1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping