CRCS3 FISH Probe
The CRCS3 FISH probe is designed to hybridize to the CRCS3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMAD7-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-RE | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-GO | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-GR | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-AQ | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-DIG | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Details
Gene Symbol: SMAD7
Gene Name: SMAD Family Member 7
Chromosome: CHR18: 46446222-46477081
Locus: 18q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CRCS3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SMAD7-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping