CPSF4 FISH Probe
The CPSF4 FISH probe is designed to hybridize to the CPSF4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CPSF4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-RE | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-GO | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-GR | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-AQ | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-DIG | 20 (40 μL) | 200 μL |  |
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| CPSF4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CPSF4
Gene Name: Cleavage And Polyadenylation Specific Factor 4
Chromosome: CHR7: 99036562-99054996
Locus: 7q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CPSF4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CPSF4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping