CPI-B FISH Probe
The CPI-B FISH probe is designed to hybridize to the CPI-B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CSTB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CSTB-20-RE | 20 (40 μL) | 200 μL |  |
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| CSTB-20-GO | 20 (40 μL) | 200 μL |  |
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| CSTB-20-GR | 20 (40 μL) | 200 μL |  |
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| CSTB-20-AQ | 20 (40 μL) | 200 μL |  |
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| CSTB-20-DIG | 20 (40 μL) | 200 μL |  |
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| CSTB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: CSTB
Gene Name: Cystatin B
Chromosome: CHR21: 45193830-45196259
Locus: 21q22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CPI-B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CSTB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping