COMT FISH Probe
The COMT FISH probe is designed to hybridize to the COMT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COMT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| COMT-20-RE | 20 (40 μL) | 200 μL |  |
|
| COMT-20-GO | 20 (40 μL) | 200 μL |  |
|
| COMT-20-GR | 20 (40 μL) | 200 μL |  |
|
| COMT-20-AQ | 20 (40 μL) | 200 μL |  |
|
| COMT-20-DIG | 20 (40 μL) | 200 μL |  |
|
| COMT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Details
Gene Symbol: COMT
Gene Name: Catechol-O-methyltransferase
Chromosome: CHR22: 19929262-19957498
Locus: 22q11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: COMT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: COMT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping