CLCF1 FISH Probe
The CLCF1 FISH probe is designed to hybridize to the CLCF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CLCF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-RE | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-GO | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-GR | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| CLCF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: CLCF1
Gene Name: Cardiotrophin Like Cytokine Factor 1
Chromosome: CHR11: 67131638-67141648
Locus: 11q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CLCF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CLCF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping