CIITA FISH Probe
The CIITA FISH probe is designed to hybridize to the CIITA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CIITA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CIITA-20-RE | 20 (40 μL) | 200 μL |  |
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| CIITA-20-GO | 20 (40 μL) | 200 μL |  |
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| CIITA-20-GR | 20 (40 μL) | 200 μL |  |
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| CIITA-20-AQ | 20 (40 μL) | 200 μL |  |
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| CIITA-20-DIG | 20 (40 μL) | 200 μL |  |
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| CIITA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Details
Gene Symbol: CIITA
Gene Name: Class II Major Histocompatibility Complex Transactivator
Chromosome: CHR16: 10971054-11018840
Locus: 16p13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CIITA FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CIITA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping