CDKN1A FISH Probe
The CDKN1A FISH probe is designed to hybridize to the CDKN1A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDKN1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-RE | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-GO | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-GR | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| CDKN1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: CDKN1A
Gene Name: Cyclin Dependent Kinase Inhibitor 1A
Chromosome: CHR6: 36644236-36655116
Locus: 6p21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CDKN1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CDKN1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping