CBFA2T2 FISH Probe
The CBFA2T2 FISH probe is designed to hybridize to the CBFA2T2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CBFA2T2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-RE | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-GO | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-GR | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CBFA2T2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CBFA2T2
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927-32237837
Locus: 20q11.21-q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CBFA2T2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CBFA2T2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping