C76846 FISH Probe
The C76846 FISH probe is designed to hybridize to the C76846 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHMP4B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-RE | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-GO | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-GR | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-AQ | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-DIG | 20 (40 μL) | 200 μL |  |
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| CHMP4B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: CHMP4B
Gene Name: Charged Multivesicular Body Protein 4B
Chromosome: CHR20: 32399109-32442173
Locus: 20q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: C76846 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CHMP4B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping