BRCA1 FISH Probe
The BRCA1 FISH probe is designed to hybridize to the BRCA1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BRCA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-RE | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-GO | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-GR | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-AQ | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-DIG | 20 (40 μL) | 200 μL |  |
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| BRCA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Gene Details
Gene Symbol: BRCA1
Gene Name: BRCA1, DNA Repair Associated
Chromosome: CHR17: 41196311-41277500
Locus: 17q21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BRCA1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BRCA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping