BFD FISH Probe
The BFD FISH probe is designed to hybridize to the BFD gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CFB-20-RE | 20 (40 μL) | 200 μL |  |
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| CFB-20-GO | 20 (40 μL) | 200 μL |  |
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| CFB-20-GR | 20 (40 μL) | 200 μL |  |
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| CFB-20-AQ | 20 (40 μL) | 200 μL |  |
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| CFB-20-DIG | 20 (40 μL) | 200 μL |  |
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| CFB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CFB
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308-3205449
Locus: 6p21.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BFD FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CFB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping