BETA-TRCP FISH Probe
The BETA-TRCP FISH probe is designed to hybridize to the BETA-TRCP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BTRC-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BTRC-20-RE | 20 (40 μL) | 200 μL |  |
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| BTRC-20-GO | 20 (40 μL) | 200 μL |  |
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| BTRC-20-GR | 20 (40 μL) | 200 μL |  |
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| BTRC-20-AQ | 20 (40 μL) | 200 μL |  |
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| BTRC-20-DIG | 20 (40 μL) | 200 μL |  |
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| BTRC-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Gene Details
Gene Symbol: BTRC
Gene Name: Beta-transducin Repeat Containing E3 Ubiquitin Protein Ligase
Chromosome: CHR10: 103113824-103317070
Locus: 10q24.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BETA-TRCP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BTRC-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping