B7-H FISH Probe
The B7-H FISH probe is designed to hybridize to the B7-H gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CD274-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CD274-20-RE | 20 (40 μL) | 200 μL |  |
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| CD274-20-GO | 20 (40 μL) | 200 μL |  |
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| CD274-20-GR | 20 (40 μL) | 200 μL |  |
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| CD274-20-AQ | 20 (40 μL) | 200 μL |  |
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| CD274-20-DIG | 20 (40 μL) | 200 μL |  |
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| CD274-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: CD274
Gene Name: CD274 Molecule
Chromosome: CHR9: 5450502-5470567
Locus: 9p24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: B7-H FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CD274-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping