ARPP-90 FISH Probe
The ARPP-90 FISH probe is designed to hybridize to the ARPP-90 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAP1GAP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-RE | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-GO | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-GR | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-AQ | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-DIG | 20 (40 μL) | 200 μL |  |
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| RAP1GAP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: RAP1GAP
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707-21995856
Locus: 1p36.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ARPP-90 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAP1GAP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping