APOB-100 FISH Probe
The APOB-100 FISH probe is designed to hybridize to the APOB-100 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APOB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APOB-20-RE | 20 (40 μL) | 200 μL |  |
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| APOB-20-GO | 20 (40 μL) | 200 μL |  |
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| APOB-20-GR | 20 (40 μL) | 200 μL |  |
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| APOB-20-AQ | 20 (40 μL) | 200 μL |  |
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| APOB-20-DIG | 20 (40 μL) | 200 μL |  |
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| APOB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: APOB
Gene Name: Apolipoprotein B
Chromosome: CHR2: 21224300-21266945
Locus: 2p24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APOB-100 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APOB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping