AMAP2 FISH Probe
The AMAP2 FISH probe is designed to hybridize to the AMAP2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASAP2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-RE | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-GO | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-GR | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-AQ | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-DIG | 20 (40 μL) | 200 μL |  |
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| ASAP2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Details
Gene Symbol: ASAP2
Gene Name: ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2
Chromosome: CHR2: 9346893-9545812
Locus: 2p24
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AMAP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ASAP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping