AF15Q14 FISH Probe
The AF15Q14 FISH probe is designed to hybridize to the AF15Q14 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KNL1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KNL1-20-RE | 20 (40 μL) | 200 μL |  |
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| KNL1-20-GO | 20 (40 μL) | 200 μL |  |
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| KNL1-20-GR | 20 (40 μL) | 200 μL |  |
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| KNL1-20-AQ | 20 (40 μL) | 200 μL |  |
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| KNL1-20-DIG | 20 (40 μL) | 200 μL |  |
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| KNL1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: KNL1
Gene Name: Kinetochore Scaffold 1
Chromosome: CHR15: 40594011-40664341
Locus: 15q15.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: AF15Q14 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KNL1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping