ADDL FISH Probe
The ADDL FISH probe is designed to hybridize to the ADDL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADD3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ADD3-20-RE | 20 (40 μL) | 200 μL |  |
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| ADD3-20-GO | 20 (40 μL) | 200 μL |  |
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| ADD3-20-GR | 20 (40 μL) | 200 μL |  |
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| ADD3-20-AQ | 20 (40 μL) | 200 μL |  |
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| ADD3-20-DIG | 20 (40 μL) | 200 μL |  |
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| ADD3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ADD3
Gene Name: Adducin 3
Chromosome: CHR10: 111765725-111895323
Locus: 10q25.1-q25.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ADDL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ADD3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping