ADAM17 FISH Probe
The ADAM17 FISH probe is designed to hybridize to the ADAM17 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAM17-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-RE | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-GO | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-GR | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-AQ | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-DIG | 20 (40 μL) | 200 μL |  |
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| ADAM17-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: ADAM17
Gene Name: ADAM Metallopeptidase Domain 17
Chromosome: CHR2: 9629410-9695917
Locus: 2p25.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ADAM17 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ADAM17-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping