53BP1 FISH Probe
The 53BP1 FISH probe is designed to hybridize to the 53BP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TP53BP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-RE | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-GO | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-GR | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: TP53BP1
Gene Name: Tumor Protein P53 Binding Protein 1
Chromosome: CHR15: 43699411-43802707
Locus: 15q15.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 53BP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TP53BP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping