5-MCDG FISH Probe
The 5-MCDG FISH probe is designed to hybridize to the 5-MCDG gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TDG-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TDG-20-RE | 20 (40 μL) | 200 μL |  |
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| TDG-20-GO | 20 (40 μL) | 200 μL |  |
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| TDG-20-GR | 20 (40 μL) | 200 μL |  |
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| TDG-20-AQ | 20 (40 μL) | 200 μL |  |
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| TDG-20-DIG | 20 (40 μL) | 200 μL |  |
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| TDG-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: TDG
Gene Name: Thymine DNA Glycosylase
Chromosome: CHR12: 104359592-104382656
Locus: 12q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 5-MCDG FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TDG-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping