2-MMP FISH Probe
The 2-MMP FISH probe is designed to hybridize to the 2-MMP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MMP2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-RE | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-GO | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-GR | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-AQ | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-DIG | 20 (40 μL) | 200 μL |  |
|
| MMP2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Gene Details
Gene Symbol: MMP2
Gene Name: Matrix Metallopeptidase 2
Chromosome: CHR16: 55513080-55540586
Locus: 16q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: 2-MMP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MMP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping