18C15.5 FISH Probe
The 18C15.5 FISH probe is designed to hybridize to the 18C15.5 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DCX-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DCX-20-RE | 20 (40 μL) | 200 μL |  |
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| DCX-20-GO | 20 (40 μL) | 200 μL |  |
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| DCX-20-GR | 20 (40 μL) | 200 μL |  |
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| DCX-20-AQ | 20 (40 μL) | 200 μL |  |
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| DCX-20-DIG | 20 (40 μL) | 200 μL |  |
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| DCX-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Details
Gene Symbol: DCX
Gene Name: Doublecortin
Chromosome: CHRX: 110537006-110655460
Locus: Xq23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: 18C15.5 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DCX-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping