PXK-FLNB Fusion FISH Probe
The PXK-FLNB Fusion FISH Probe is used to confirm a fusion of the PXK and FLNB genes. The fusion of the PXK and FLNB genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PXK-FLNB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-RERE | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-REOR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-REGO | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-REGR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-REAQ | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-ORRE | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-OROR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-ORGO | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-ORAQ | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GORE | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GOOR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GOGO | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GOGR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GOAQ | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GRRE | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GROR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GRGO | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GRGR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-GRAQ | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-AQRE | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-AQOR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-AQGO | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-AQGR | 20 (40 μL) | 200 μL |
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| PXK-FLNB-20-AQAQ | 20 (40 μL) | 200 μL |
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FLNB Gene Summary
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Filamin B
Chromosome: CHR3: 57994126 -58157982
Locus: 3p14.3
PXK Gene Summary
This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: PX Domain Containing Serine/threonine Kinase Like
Chromosome: CHR3: 58318616 -58410878
Locus: 3p14.3
Gene Diseases
The PXK FLNB Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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