PTK2B-ICA1L Fusion FISH Probe
The PTK2B-ICA1L Fusion FISH Probe is used to confirm a fusion of the PTK2B and ICA1L genes. The fusion of the PTK2B and ICA1L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTK2B-ICA1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-RERE | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-REOR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-REGO | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-REGR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-REAQ | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-ORRE | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-OROR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-ORGO | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GORE | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GOOR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GOGO | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GOGR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GRRE | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GROR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GRGO | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GRGR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-AQRE | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-AQOR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-AQGO | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-AQGR | 20 (40 μL) | 200 μL |
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| PTK2B-ICA1L-20-AQAQ | 20 (40 μL) | 200 μL |
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PTK2B Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Kinase 2 Beta
Chromosome: CHR8: 27168998 -27316908
Locus: 8p21.2
ICA1L Gene Summary
The Islet Cell Autoantigen 1 Like (ICA1L) gene is located on chr2 :203637872-203736371 at 2q33.2.
Gene Name: Islet Cell Autoantigen 1 Like
Chromosome: CHR2: 203637872 -203736371
Locus: 2q33.2
Gene Diseases
The PTK2B ICA1L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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