PPP1CA-PPP2R3C Fusion FISH Probe
The PPP1CA-PPP2R3C Fusion FISH Probe is used to confirm a fusion of the PPP1CA and PPP2R3C genes. The fusion of the PPP1CA and PPP2R3C genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1CA-PPP2R3C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1CA-PPP2R3C-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1CA Gene Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Catalytic Subunit Alpha
Chromosome: CHR11: 67165651 -67169376
Locus: 11q13.2
PPP2R3C Gene Summary
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B''gamma
Chromosome: CHR14: 35554677 -35591519
Locus: 14q13.2
Gene Diseases
The PPP1CA PPP2R3C Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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