DENND1A-CADPS2 Fusion FISH Probe
The DENND1A-CADPS2 Fusion FISH Probe is used to confirm a fusion of the DENND1A and CADPS2 genes. The fusion of the DENND1A and CADPS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-CADPS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-CADPS2-20-AQAQ | 20 (40 μL) | 200 μL |
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DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
CADPS2 Gene Summary
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Calcium Dependent Secretion Activator 2
Chromosome: CHR7: 121958477 -122526813
Locus: 7q31.32
Gene Diseases
The DENND1A CADPS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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